Document Detail

Morphine hyperthermia in the rat: its attenuation by physostigmine.
MedLine Citation:
PMID:  5040664     Owner:  NLM     Status:  MEDLINE    
1. In rats, a subcutaneous injection of morphine (2.5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0.1 mg/kg), but not of neostigmine (0.08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine.2. It is concluded that the hyperthermia is a specific response to morphine, central in origin, and the result of diminished acetylcholine (ACh) release from central cholinergic neurones.
M Sharkawi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  44     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1972 Mar 
Date Detail:
Created Date:  1972-09-06     Completed Date:  1972-09-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  544-8     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / metabolism
Body Temperature / drug effects
Central Nervous System / metabolism
Fever / chemically induced*
Injections, Intraperitoneal
Injections, Subcutaneous
Morphine / administration & dosage,  antagonists & inhibitors*
Nalorphine / pharmacology
Neostigmine / pharmacology
Neurons / metabolism
Physostigmine / administration & dosage,  pharmacology*
Reg. No./Substance:
51-84-3/Acetylcholine; 57-27-2/Morphine; 57-47-6/Physostigmine; 59-99-4/Neostigmine; 62-67-9/Nalorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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