| Morphine hyperthermia in the rat: its attenuation by physostigmine. | |
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MedLine Citation:
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PMID: 5040664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In rats, a subcutaneous injection of morphine (2.5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0.1 mg/kg), but not of neostigmine (0.08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine.2. It is concluded that the hyperthermia is a specific response to morphine, central in origin, and the result of diminished acetylcholine (ACh) release from central cholinergic neurones. |
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Authors:
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M Sharkawi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 44 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1972 Mar |
Date Detail:
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Created Date: 1972-09-06 Completed Date: 1972-09-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 544-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Animals Body Temperature / drug effects Central Nervous System / metabolism Female Fever / chemically induced* Injections, Intraperitoneal Injections, Subcutaneous Morphine / administration & dosage, antagonists & inhibitors* Nalorphine / pharmacology Neostigmine / pharmacology Neurons / metabolism Physostigmine / administration & dosage, pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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51-84-3/Acetylcholine; 57-27-2/Morphine; 57-47-6/Physostigmine; 59-99-4/Neostigmine; 62-67-9/Nalorphine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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