Document Detail

Morphea and other localized forms of scleroderma.
MedLine Citation:
PMID:  23018858     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: Morphea, also known as localized scleroderma, is a disorder of excessive collagen deposition leading to thickening of the dermis and/or subcutaneous tissues and may cause significant morbidity. This review will describe new developments in the evaluation and management of morphea as well as its pathophysiology. The reader will be able to apply these findings to patient management.
RECENT FINDINGS: The recent development of validated outcome measures (i.e. the localized scleroderma cutaneous assessment tool) as well as consensus treatment recommendations provide a platform for collaboration among specialties to develop both standardized assessment tools and therapeutic trials. New studies have also begun to investigate the immunological underpinnings of morphea.
SUMMARY: The promise of evidence-based treatments for morphea in the near future will provide better care for patients with morphea and understanding its pathophysiology will lay groundwork for the development of new treatments.
Rebecca Vasquez; Chelsea Sendejo; Heidi Jacobe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  24     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  685-93     Citation Subset:  IM    
aDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas bUniversity of Texas Pan American, Edinburg, Texas, USA.
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