Document Detail

Morning cortisol in relation to behavioral symptoms of nursing home residents with dementia.
MedLine Citation:
PMID:  21112915     Owner:  NLM     Status:  MEDLINE    
METHOD: Using a within-subject longitudinal design, saliva was collected four times daily for 5 days to obtain basal cortisol levels from 30 NH residents, aged 80 to 102. Behavior was observed every 20 min for 12 hr/day for 5 days. Mixed-model analysis was used to test the association between morning cortisol (MC) and BSD. To examine the association between MC and BSD across time, participants were divided into low (LM) and high morning (HM) cortisol groups.
RESULTS: A significant inverse association between mean overall BSD and morning cortisol (F = 12.71, p = .000) was found. A significant inverse association between low and high morning cortisol and behavior variability across time (F = 15.36. p = .000) was found. The LM group exhibited significantly more behavioral variability across the day than the HM cortisol group. There was a significant group difference between two co-occurring behaviors, vocalization, and restlessness (F = 19.59, p = .000).
CONCLUSION: Although preliminary, these results suggest an association between morning cortisol and BSD. Low morning cortisol, potentially indicating HPA axis dysregulation, may increase vulnerability to BSD.
Diana Lynn Woods; Haesook Kim; Maria Yefimova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-26
Journal Detail:
Title:  Biological research for nursing     Volume:  13     ISSN:  1552-4175     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-16     Completed Date:  2011-07-12     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM; N    
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MeSH Terms
Aged, 80 and over
Circadian Rhythm
Dementia / metabolism*
Hydrocortisone / analysis*
Nursing Homes*
Saliva / chemistry*
Reg. No./Substance:

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