| More than nervous: The emerging roles of plexins. | |
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MedLine Citation:
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PMID: 22099179 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Plexins are the receptors for semaphorins, a large family of axon guidance cues. Accordingly, the role of plexins in the development of the nervous system was the first to be acknowledged. However, the expression of plexins is not restricted to neuronal cells, and recent research has been increasingly focused on the roles of plexin-semaphorin signalling outside of the nervous system. During embryogenesis, plexins regulate the development of many organs, including the cardiovascular system, skeleton and kidney. They have also been shown to be involved in immune system functions and tumour progression. Analyses of the plexin signalling in different tissues and cell types have provided new insight to the versatility of plexin interactions with semaphorins and other cell-surface receptors. In this review we try to summarise the current understanding of the roles of plexins in non-neural development and immunity. |
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Authors:
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Nina Perälä; Hannu Sariola; Tiina Immonen |
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Publication Detail:
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Type: Journal Article Date: 2011-10-14 |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: 83 ISSN: 1432-0436 ISO Abbreviation: Differentiation Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: England |
Other Details:
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Languages: eng Pagination: 77-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Institute of Biomedicine/Biochemistry and Developmental Biology, Biomedicum Helsinki, University of Helsinki, P.O. Box 63, FI-00014 Helsinki, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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