| More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases. | |
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MedLine Citation:
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PMID: 21395384 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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T-bet was initially described as a T-box transcription factor with an essential role in orchestrating Th1 cell differentiation. Subsequently, it was determined that T-bet controls the expression of numerous cytokines and their receptors, adhesion molecules and chemokine receptors, and therefore determines the differentiation and development status of many types of immune cells. The critical role of T-bet in autoimmune diseases, particularly multiple sclerosis and its animal model experimental autoimmune encephalomyelitis, implicates it as a potential biomarker for pathogenic T cells as well as a therapeutic drug target. |
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Authors:
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Niannian Ji; Rebecca A Sosa; Thomas G Forsthuber |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunotherapy Volume: 3 ISSN: 1750-7448 ISO Abbreviation: Immunotherapy Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485158 Medline TA: Immunotherapy Country: England |
Other Details:
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Languages: eng Pagination: 435-41 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Texas at San Antonio, TX 78249, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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