| More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings. | |
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MedLine Citation:
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PMID: 18932105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to determine the frequency, severity and outcome of cardiac findings in patients with acute Puumala hantavirus-induced nephropathia epidemica (NE). 70 consecutive, hospital-treated patients with serologically confirmed NE were prospectively examined using serial electrocardiograms (ECG), plasma troponin I, tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and echocardiography (ECHO). Examinations were repeated after 3 and 12 months. ECG changes were observed in 57% of patients. Plasma troponin I levels remained normal in all. In six patients, ECHO showed left ventricular contraction abnormalities, and 1 patient had mild pericardial effusion. There were no differences in clinical or standard laboratory findings or in plasma TNF-alpha and IL-6 concentrations between patients with and without ECG or ECHO changes. During the follow-up, all acute-phase changes in ECG and ECHO reverted to normal, which probably reflects their benign nature. We conclude that abnormal cardiac findings are surprisingly common during NE. |
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Authors:
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Satu Makela; Liisa Kokkonen; Ilpo Ala-Houhala; Kaj Groundstroem; Aimo Harmoinen; Heini Huhtala; Mikko Hurme; Antti Paakkala; Ilkka Porsti; Vesa Virtanen; Antti Vaheri; Jukka Mustonen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 41 ISSN: 0036-5548 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: Sweden |
Other Details:
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Languages: eng Pagination: 57-62 Citation Subset: IM |
Affiliation:
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Medical School, University of Tampere, Finland. satu.marjo.makela@uta.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Echocardiography Electrocardiography Female Finland / epidemiology Hemorrhagic Fever with Renal Syndrome / physiopathology*, virology* Hospitals, University Humans Male Middle Aged Pericardial Effusion / diagnosis, epidemiology* Puumala virus / pathogenicity* Severity of Illness Index Ventricular Dysfunction, Left / diagnosis, epidemiology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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