Document Detail

More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings.
MedLine Citation:
PMID:  18932105     Owner:  NLM     Status:  MEDLINE    
This study was conducted to determine the frequency, severity and outcome of cardiac findings in patients with acute Puumala hantavirus-induced nephropathia epidemica (NE). 70 consecutive, hospital-treated patients with serologically confirmed NE were prospectively examined using serial electrocardiograms (ECG), plasma troponin I, tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and echocardiography (ECHO). Examinations were repeated after 3 and 12 months. ECG changes were observed in 57% of patients. Plasma troponin I levels remained normal in all. In six patients, ECHO showed left ventricular contraction abnormalities, and 1 patient had mild pericardial effusion. There were no differences in clinical or standard laboratory findings or in plasma TNF-alpha and IL-6 concentrations between patients with and without ECG or ECHO changes. During the follow-up, all acute-phase changes in ECG and ECHO reverted to normal, which probably reflects their benign nature. We conclude that abnormal cardiac findings are surprisingly common during NE.
Satu Makela; Liisa Kokkonen; Ilpo Ala-Houhala; Kaj Groundstroem; Aimo Harmoinen; Heini Huhtala; Mikko Hurme; Antti Paakkala; Ilkka Porsti; Vesa Virtanen; Antti Vaheri; Jukka Mustonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  41     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Medical School, University of Tampere, Finland.
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MeSH Terms
Acute Disease
Finland / epidemiology
Hemorrhagic Fever with Renal Syndrome / physiopathology*,  virology*
Hospitals, University
Middle Aged
Pericardial Effusion / diagnosis,  epidemiology*
Puumala virus / pathogenicity*
Severity of Illness Index
Ventricular Dysfunction, Left / diagnosis,  epidemiology*
Young Adult

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