Document Detail

More outcomes than trials: a call for consistent data collection across stroke rehabilitation trials.
MedLine Citation:
PMID:  23280265     Owner:  NLM     Status:  MEDLINE    
Stroke survivors experience complex combinations of impairments, activity limitations, and participation restrictions. The essential components of stroke rehabilitation remain elusive. Determining efficacy in randomized controlled trials (RCTs) is challenging; there is no commonly agreed primary outcome measure for rehabilitation trials. Clinical guidelines depend on proof of efficacy in RCTs and meta-analyses. However, diverse trial aims, differing methods, inconsistent data collection, and use of multiple assessment tools hinder comparability across trials. Consistent data collection in acute stroke trials has facilitated meta-analyses to inform trial design and clinical practice. With few exceptions, inconsistent data collection has hindered similar progress in stroke rehabilitation research. There is an urgent need for the routine collection of a core dataset of common variables in rehabilitation trials. The European Stroke Organisation Outcomes Working Group, the National Institutes of Neurological Disorders and Stroke Common Data Elements project, and the Collaborative Stroke Audit and Research project have called for consistency in data collection in stroke trials. Standardizing data collection can decrease study start up times, facilitate data sharing, and inform clinical guidelines. Although achieving consensus on which outcome measures to use in stroke rehabilitation trials is a considerable task, perhaps a feasible starting point is to achieve consistency in the collection of data on demography, stroke severity, and stroke onset to inclusion times. Longer term goals could include the development of a consensus process to establish the core dataset. This should be endorsed by researchers, funders, and journal editors in order to facilitate sustainable change.
M Ali; C English; J Bernhardt; K S Sunnerhagen; M Brady;
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of stroke : official journal of the International Stroke Society     Volume:  8     ISSN:  1747-4949     ISO Abbreviation:  Int J Stroke     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-07     Revised Date:  2014-06-20    
Medline Journal Info:
Nlm Unique ID:  101274068     Medline TA:  Int J Stroke     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.
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MeSH Terms
Clinical Trials as Topic / methods,  standards*
Data Collection / methods,  standards*
Outcome Assessment (Health Care) / methods
Research Design / standards*
Stroke / rehabilitation*
Grant Support
08/14/51//Department of Health; G0902303//Medical Research Council; HTA/08/14/51//Department of Health
M Brady / ; M Ali / ; A Ashburn / ; D Barer / ; J Bernhardt / ; A Bowen / ; E Brodie / ; S Corr / ; A Drummond / ; J Edmans / ; C English / ; J Gladman / ; T Hoffmann / ; L Kalra / ; S Kuys / ; P Langhorne / ; K R Lees / ; N Lincoln / ; P Logan / ; L Jongbloed / ; G Mead / ; A Pollock / ; V Pomeroy / ; H Rodgers / ; C Sackley / ; L Shaw / ; D J Stott / ; K S Sunnerhagen / ; S Tyson / ; P van Vliet / ; M Walker / ; W Whiteley /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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