| More extensive genetic alterations in unmutated than in hypermutated cases of chronic lymphocytic leukemia. | |
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MedLine Citation:
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PMID: 12800154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B-cell chronic lymphocytic leukemia (CLL) is not a uniform disease entity; approximately half of the CLL cases have undergone immunoglobulin V(H) gene hypermutation, whereas the other half display unmutated V(H) genes. We investigated genome changes in 12 hypermutated cases (M-CLL) and 22 unmutated cases (UM-CLL) by use of comparative genomic hybridization, G-banding, and multicolor fluorescence in situ hybridization (m-FISH) after optimal mitogen stimulation and FISH analysis of typical CLL aberrations: 11q deletion, 13q deletion, and trisomy 12. Very high frequencies of aberrations were found in both groups: 82% in UM-CLL and 83% in M-CLL. Deletions of 11q and 13q were equally distributed in M-CLL and UM-CLL. However, larger aberrations detectable by CGH, trisomy 12, and complex aberrations were less frequent in M-CLL than in UM-CLL. These observations led to a hypothesis that unmutated and mutated CLL have different biological Backgrounds, given that large and/or complex chromosomal aberrations and hypermutation of the CLL progenitor cells tend to be mutually exclusive. |
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Authors:
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Ritva Karhu; Gerard Tobin; Ulf Thunberg; Leena Vilpo; Christer Sundström; Sakari Knuutila; Richard Rosenquist; Juhani Vilpo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes, chromosomes & cancer Volume: 37 ISSN: 1045-2257 ISO Abbreviation: Genes Chromosomes Cancer Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-06-11 Completed Date: 2003-08-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007329 Medline TA: Genes Chromosomes Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 417-20 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Laboratory of Cancer Genetics, University of Tampere and Tampere University Hospital, Tampere, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Chromosome Deletion Female Gene Amplification / genetics Humans Immunoglobulin Heavy Chains / genetics Immunoglobulin Variable Region / genetics Karyotyping Leukemia, Lymphocytic, Chronic, B-Cell / genetics* Male |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Variable Region |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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