Document Detail

More chores for TOR: de novo ceramide synthesis.
MedLine Citation:
PMID:  18249168     Owner:  NLM     Status:  MEDLINE    
In this issue of Cell Metabolism, Aronova et al. (2008) show that target of rapamycin complex 2 (TORC2) controls de novo ceramide synthesis in yeast by regulating the activity of ceramide synthase. This work may provide insight into how chemotherapeutic drugs increase de novo ceramide synthesis and promote cell death in humans.
Robert C Dickson
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  7     ISSN:  1550-4131     ISO Abbreviation:  Cell Metab.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-100     Citation Subset:  IM    
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA. <>
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MeSH Terms
1-Phosphatidylinositol 3-Kinase / physiology*
Cell Cycle Proteins / physiology*
Ceramides / biosynthesis*
Oxidoreductases / metabolism
Saccharomyces cerevisiae Proteins / physiology*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Ceramides; 0/Saccharomyces cerevisiae Proteins; EC 1.-/Oxidoreductases; EC 1.3.1.-/dihydroceramide desaturase; EC 3-Kinase; EC protein, S cerevisiae
Comment On:
Cell Metab. 2008 Feb;7(2):148-58   [PMID:  18249174 ]

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