| More chores for TOR: de novo ceramide synthesis. | |
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MedLine Citation:
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PMID: 18249168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this issue of Cell Metabolism, Aronova et al. (2008) show that target of rapamycin complex 2 (TORC2) controls de novo ceramide synthesis in yeast by regulating the activity of ceramide synthase. This work may provide insight into how chemotherapeutic drugs increase de novo ceramide synthesis and promote cell death in humans. |
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Authors:
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Robert C Dickson |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell metabolism Volume: 7 ISSN: 1550-4131 ISO Abbreviation: Cell Metab. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 99-100 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA. bobd@uky.edu <bobd@uky.edu> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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physiology* Cell Cycle Proteins / physiology* Ceramides / biosynthesis* Oxidoreductases / metabolism Saccharomyces cerevisiae Proteins / physiology* Yeasts |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Ceramides; 0/Saccharomyces cerevisiae Proteins; EC 1.-/Oxidoreductases; EC 1.3.1.-/dihydroceramide desaturase; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.1.137/TOR2 protein, S cerevisiae |
| Comments/Corrections | |
Comment On:
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Cell Metab. 2008 Feb;7(2):148-58
[PMID:
18249174
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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