Document Detail

Morbidity and mortality in 46 patients with the VACTERL association.
MedLine Citation:
PMID:  1597357     Owner:  NLM     Status:  MEDLINE    
During a 10-year period, 313 infants were treated at the Hospital for Sick Children for esophageal atresia, of whom 46 had features of the VACTERL association. These 46 patients had a mortality rate of 24%, most deaths being caused by cardiovascular abnormalities. Infants weighing less than 2,050 g had a mortality rate of 26%, double that of heavier infants. During the first year of life there was considerable morbidity resulting from the tracheoesophageal abnormalities. Whenever possible primary repair of the esophagus should be performed; however, many patients with VACTERL association had an unusually long gap between the two ends of the esophagus, and repair under tension was associated with a high incidence of complications. Of the 35 survivors, 25 are in a satisfactory, stable condition, but 10 still require treatment necessitating repeated admission to hospital. Anorectal, renal or skeletal anomalies rarely caused death, but, when severe, were associated with a poor quality of life.
M Iuchtman; R Brereton; L Spitz; E M Kiely; D Drake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  28     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-08     Completed Date:  1992-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  281-4     Citation Subset:  IM    
Department of Pediatric Surgery, Hospital for Sick Children, London, UK.
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MeSH Terms
Abnormalities, Multiple / epidemiology*,  mortality
Esophageal Atresia / epidemiology*,  mortality,  surgery
Infant, Newborn

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