Document Detail

Morbidity and mortality of hepatic resection for metastatic colorectal carcinoma.
MedLine Citation:
PMID:  2158418     Owner:  NLM     Status:  MEDLINE    
Hepatic resection is the only curative therapy currently available for colorectal cancer metastases to the liver. However, concern over high morbidity and mortality of the procedure has limited referral of patients for resection. The authors report on 58 patients undergoing hepatic resection for colorectal metastases at the National Cancer Institute between the years 1976 and 1985. Thirty-two patients underwent a major hepatic resection, and 26 patients underwent one or more wedge resections. Mean anesthesia time was 448 minutes, mean estimated blood loss was 3663 ml, and mean hospital stay was 17.5 days. Operative mortality was 3 percent, and morbidity was 62 percent. Using a grading scale for complications, 24 percent of patients had inconsequential complications, 16 percent had moderate complications, and 19 percent had severe complications. Complications were clearly related to extent of procedure. Factors that correlated best with morbidity were high blood loss and trisegmentectomy. The authors conclude that while hepatic resection can carry a high morbidity, much of this morbidity is minor and operative mortality is low. Recent improvements in anesthesia, improved resection technique, and a better understanding of hepatic anatomy have made possible correspondingly lower morbidity and mortality rates. Careful selection of patients can make hepatic resection a safe procedure.
J T Vetto; K S Hughes; R Rosenstein; P H Sugarbaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  33     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-13     Citation Subset:  IM    
Department of Surgery, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
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MeSH Terms
Anesthesia, General
Carcinoma / mortality,  pathology*,  surgery
Carcinoma, Hepatocellular / secondary*,  surgery*
Colorectal Neoplasms / mortality,  pathology*,  surgery
Hemorrhage / etiology
Length of Stay
Liver Neoplasms / secondary*,  surgery*
Postoperative Complications
Retrospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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