Document Detail

Morbidity, mortality and coronavirus antigen in previously coronavirus free kittens placed in two catteries with feline infectious peritonitis.
MedLine Citation:
PMID:  8266899     Owner:  NLM     Status:  MEDLINE    
Serologically coronavirus free kittens were placed in 2 catteries with a history of feline infectious peritonitis (FIP), each cattery representing 1 of the 2 different predominant clinical characteristics of FIP--effusive and granulomatous. The kittens were clinically observed for 100 days. A 100% morbidity and a 90% mortality was observed. The first signs were observed after 14 and 27 days respectively. The clinical pattern of the disease was similar in all kittens and showed a pattern of recurrent periods of conjunctivitis, upper respiratory and gastrointestinal signs. Once developed, wasting and signs of CNS disturbances were consistent. The "effusive strain" had a 2 weeks earlier onset of signs and death, and a 40% outcome of effusive FIP. Mean survival times during the observation period were 57 +/- 26 and 57 +/- 16 (mean +/- SD in days), respectively. The death rates were similar in both groups. Feline coronavirus (FCoV) antigen was immunohistochemically detected using indirect immunofluorescence and was present in all kittens and in 93% of the 5 investigated organs (lung, liver, spleen, kidney, and mesenteric lymph node).
K Hök
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta veterinaria Scandinavica     Volume:  34     ISSN:  0044-605X     ISO Abbreviation:  Acta Vet. Scand.     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370400     Medline TA:  Acta Vet Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Department of Medical Microbial Ecology, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Antigens, Viral / immunology*
Coronavirus, Feline / immunology*
Feline Infectious Peritonitis / immunology,  mortality*
Survival Rate
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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