Document Detail

Morbidity in former sawmill workers exposed to pentachlorophenol (PCP): a cross-sectional study in New Zealand.
MedLine Citation:
PMID:  19152355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: From 1950 to 1990 pentachlorophenol (PCP) was used widely in the New Zealand sawmill industry, and persistent claims of long-term health effects have been made. METHODS: We surveyed surviving members of a cohort enumerated to study mortality in sawmill workers employed from 1970 to 1990. Estimates of historical exposure were based on job titles held, using the results of a PCP biomonitoring survey conducted in the 1980s. The survey involved interviews and clinical examinations, with interviewers and examiners blinded to exposure status. RESULTS: Of the 293 participants 177 had not been exposed, and of the 116 exposed all but 10% had low or short-term PCP exposure. Nevertheless, a number of significant associations between PCP exposure and the prevalence of various symptoms were observed including associations between: (i) exposure levels and self-reported tuberculosis, pleurisy or pneumonia (P < 0.01) and a deficit in cranial nerve function (P = 0.04); (ii) duration of employment and thyroid disorders (P = 0.04), and neuropsychological symptoms including often going back to check things (P = 0.04), low libido (P = 0.02) and heart palpitations (P = 0.02), and a strong dose-response trend for frequent mood changes without cause (P < 0.01); and (iii) cumulative exposure and frequent mood changes without cause (P = 0.02), low libido (P = 0.04), and in the overall number of neuropsychological symptoms reported (P = 0.03). CONCLUSIONS: PCP exposure was associated with a number of physical and neuropsychological health effects that persisted long after exposure had ceased.
David McLean; Amanda Eng; Evan Dryson; Chris Walls; Elizabeth Harding; Khoon Ching Wong; Soo Cheng; Andrea't Mannetje; Lis Ellison-Loschmann; Tania Slater; Phil Shoemack; Neil Pearce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  52     ISSN:  1097-0274     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-81     Citation Subset:  IM    
Centre for Public Health Research, Massey University, Wellington, New Zealand.
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MeSH Terms
Cross-Sectional Studies
Interviews as Topic
Logistic Models
Middle Aged
New Zealand / epidemiology
Occupational Diseases / epidemiology*
Occupational Exposure / adverse effects*
Pentachlorophenol / poisoning*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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