| Morbidity and Mortality in Klinefelter Syndrome, (47,XXY). | |
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MedLine Citation:
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PMID: 21414026 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Klinefelter syndrome (KS) (47,XXY) is the most common sex chromosome disorder in man, and is a relatively common cause of male infertility and hypogonadism. The syndrome has been known since 1942 and many reports of different diseases associated with KS have been reported since that, but a more systematic knowledge about the long-term outcome was not described until the last decade, where nation-wide epidemiological studies were reported from Britain and Denmark. We here review the epidemiological data from two cohorts of KS patients in Denmark and Britain, showing a significant increase in both mortality and morbidity from a variety of different causes. Mortality was increased by 50% (SMR 1.5 or HR 1.4) corresponding to a median loss of approximately 2 years. The risk of being admitted to hospital with any diagnosis was increased by 70%. The underlying reason for the poorer health in KS may be caused by interaction of genetic, hormonal and socio-economic factors. Conclusion: Both morbidity and mortality are significantly increased in Klinefelter syndrome with a 50% increase in mortality risk and a 70% increase in risk of being admitted to hospital. |
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Authors:
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Anders Bojesen; Claus H Gravholt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-17 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Department of Clinical Genetics, Vejle Hospital, Sygehus Lillebaelt, DK-7100, Denmark Department of Endocrinology & Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus Sygehus NBG, DK-8000 Aarhus C, Denmark. |
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