Document Detail

Morbidity and mortality of orthostatic hypotension: implications for management of cardiovascular disease.
MedLine Citation:
PMID:  20814408     Owner:  NLM     Status:  MEDLINE    
Orthostatic hypotension (OH) is the failure of cardiovascular reflexes to maintain blood pressure on standing from a supine or sitting position. Although OH may cause symptoms of dizziness or syncope, asymptomatic OH (AOH) is far more common and is an independent risk factor for mortality and cardiovascular disease (CVD). The prevalence of AOH increases with age, the presence of hypertension or diabetes and the use of antihypertensive or other medications. The implications of AOH for the treatment of CVD and hypertension are not well defined. This review provides an overview of the current information on this topic and recommends the more frequent assessment of OH in clinical practice and in future clinical trials.
Luke J Benvenuto; Lawrence R Krakoff
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-02
Journal Detail:
Title:  American journal of hypertension     Volume:  24     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-05-03     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
The Mount Sinai School of Medicine, Department of Internal Medicine, The Mount Sinai Hospital, New York, New York, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Antihypertensive Agents / adverse effects
Asymptomatic Diseases
Blood Pressure*
Cardiovascular Diseases / drug therapy,  epidemiology*,  mortality,  physiopathology
Diabetes Complications / epidemiology
Hypertension / drug therapy,  epidemiology,  physiopathology
Hypotension, Orthostatic / epidemiology*,  mortality,  physiopathology
Middle Aged
Risk Assessment
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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