Document Detail

Morbid obesity: pregnancy risks, birth risks and status of the newborn.
MedLine Citation:
PMID:  20042187     Owner:  NLM     Status:  MEDLINE    
In perinatal medicine, severe obesity of the mother occurs in approximately 1% of cases. This is a problem of increasing importance because of the rising prevalence of juvenile obesity. Our retrospective cohort study aimed at characterising high-risk pregnancies associated with morbid obesity (body mass index [BMI]> or =40). This is of interest not only from an epidemiological perspective and for developing guidelines for clinical care but also from an anthropological point of view. We analysed the German perinatal statistics of the years 1998-2000 with data from more than 500,000 pregnancies. Pregnant women with coexistent morbid obesity were compared to a normal weight reference sample with regard to gestational, perinatal and neonatal risks. Birth weight percentiles were used to classify the neonates according to size (hypotrophy if <10th, hypertrophy/foetal macrosomia if >90th). The obtained risk profile for morbidly obese pregnant women primarily showed pregnancy related diseases, such as hypertension, pre-eclampsia and gestational diabetes. Hypertension and signs of foetal hypoxaemia occurred at higher frequencies with morbid obesity. Hypertrophic neonates were born 3.3 times more often to obese mothers than to mothers of the normal weight. At a BMI> or =40 the rates of complications such as pre-eclampsia, gestational diabetes, impending foetal hypoxaemia, foetal macrosomia, as well as neonatal infections and hyperbilirubinaemia were significantly higher. Obesity and maternal comorbidities, accounted for a higher rate of caesarean sections of up to 38.4% at a BMI> or =45. All differences were highly significant. Preconceptionally, the therapeutic approach should be weight reduction.
Volker Briese; Manfred Voigt; Michael Hermanussen; Ursula Wittwer-Backofen
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-12-29
Journal Detail:
Title:  Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen     Volume:  61     ISSN:  1618-1301     ISO Abbreviation:  Homo     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374655     Medline TA:  Homo     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  64-72     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009. Published by Elsevier GmbH.
Department of Obstetrics and Gynaecology, University of Rostock, Germany.
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MeSH Terms
Birth Weight
Cohort Studies
Diabetes, Gestational / epidemiology*
Fetal Hypoxia / epidemiology*
Fetal Macrosomia / epidemiology*
Germany / epidemiology
Hyperbilirubinemia / epidemiology*
Hypertension / epidemiology*
Infant, Newborn
Obesity, Morbid / complications*,  epidemiology
Pre-Eclampsia / epidemiology*
Pregnancy Outcome
Pregnancy, High-Risk
Prenatal Care
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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