| Mood, prolactin and cortisol responses following intravenous L-tryptophan challenge: evidence for serotonergic vulnerability in first-degree relatives of bipolar patients. | |
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MedLine Citation:
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PMID: 12366878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central serotonergic vulnerability indicated by altered mood and neuroendocrine responses to an intravenous (i.v.) tryptophan (Trp) challenge was assessed in healthy adult unaffected first-degree relatives of bipolar disorder (BD) patients (n = 30) (family history; FH). The effects of a single dose of 7.0 g Trp on mood, cortisol and prolactin (Prl) in FH subjects were compared with healthy matched controls (n = 15) in a placebo-controlled, double blind cross-over design. Prl and cortisol responses increased following Trp. Overall, Trp lowered mood. Hormonal and mood effects did not differ between FH and controls. Results show some evidence for differences in serotonergic vulnerability between relatives of type I BD patients and relatives of type II BD patients. |
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Authors:
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Sjacko Sobczak; Adriaan Honig; Marlies Alice van Duinen; Michael Maes; Willem Jan Riedel |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) Volume: 5 ISSN: 1461-1457 ISO Abbreviation: Int. J. Neuropsychopharmacol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-07 Completed Date: 2003-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815893 Medline TA: Int J Neuropsychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology, Universiteit Maastricht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / drug effects* Antidepressive Agents, Second-Generation / administration & dosage, blood, diagnostic use* Bipolar Disorder / blood, genetics Female Humans Hydrocortisone / blood* Injections, Intravenous Male Prolactin / blood* Psychiatric Status Rating Scales Tryptophan / administration & dosage, blood, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 50-23-7/Hydrocortisone; 73-22-3/Tryptophan; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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