Document Detail


Mood effects of zolpidem versus phenobarbital combined with promethazine in an anesthesiological setting.
MedLine Citation:
PMID:  8904738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zolpidem, a new imidazo-pyridine hypnotic, acts like a benzodiazepine. Because of its short half-life, zolpidem plays a special role in the group of drugs suitable for anesthesiological premedication because of its sedative and anxiolytic effects. The study compared preanesthesiological treatment by zolpidem and phenobarbital in combination with promethazine in a clinical setting. In a double-blind randomized design, 304 patients awaiting different kinds of surgery were studied. For the assessment of emotional states, a multidimensional rating scale was administered. The study showed differing effects of zolpidem and phenobarbital, which could be demonstrated in the scales 'irritation', 'vulnerability', and 'aggression' and could therefore represent in domain hostility. In most of the other scales there were similar effects of phenobarbital and zolpidem. Assuming that phenobarbital is a potent sedative, the reported results confirm the results found by other authors, that zolpidem also acts as a sedative. The reported results describe promethazine as selectively deactivating. These results are in agreement with the findings of an experimental study which tested the acute effects of stress under promethazine.
Authors:
T Uhlig; M Hüppe; B Nidermaier; G Pestel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neuropsychobiology     Volume:  34     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-12     Completed Date:  1997-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
Affiliation:
Clinic of Anesthesiology, Medical University of Lübeck, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Affect / drug effects*
Age Factors
Emotions / drug effects*
Female
Humans
Hypnotics and Sedatives / pharmacology*
Male
Middle Aged
Phenobarbital / pharmacology*
Promethazine / pharmacology*
Pyridines / pharmacology*
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Pyridines; 50-06-6/Phenobarbital; 60-87-7/Promethazine; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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