Document Detail

Mood effects of zolpidem versus phenobarbital combined with promethazine in an anesthesiological setting.
MedLine Citation:
PMID:  8904738     Owner:  NLM     Status:  MEDLINE    
Zolpidem, a new imidazo-pyridine hypnotic, acts like a benzodiazepine. Because of its short half-life, zolpidem plays a special role in the group of drugs suitable for anesthesiological premedication because of its sedative and anxiolytic effects. The study compared preanesthesiological treatment by zolpidem and phenobarbital in combination with promethazine in a clinical setting. In a double-blind randomized design, 304 patients awaiting different kinds of surgery were studied. For the assessment of emotional states, a multidimensional rating scale was administered. The study showed differing effects of zolpidem and phenobarbital, which could be demonstrated in the scales 'irritation', 'vulnerability', and 'aggression' and could therefore represent in domain hostility. In most of the other scales there were similar effects of phenobarbital and zolpidem. Assuming that phenobarbital is a potent sedative, the reported results confirm the results found by other authors, that zolpidem also acts as a sedative. The reported results describe promethazine as selectively deactivating. These results are in agreement with the findings of an experimental study which tested the acute effects of stress under promethazine.
T Uhlig; M Hüppe; B Nidermaier; G Pestel
Related Documents :
24642998 - Incomplete stent apposition causes high shear flow disturbances and delay in neointimal...
23172438 - Superficial skin sensitivity impairment and skeletal stability after sagittal split ram...
12791328 - Sexual outcome after epilepsy surgery.
15304598 - A prospective analysis of the outcome of levetiracetam in clinical practice.
24642998 - Incomplete stent apposition causes high shear flow disturbances and delay in neointimal...
25002178 - Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neuropsychobiology     Volume:  34     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-12     Completed Date:  1997-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
Clinic of Anesthesiology, Medical University of Lübeck, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Affect / drug effects*
Age Factors
Emotions / drug effects*
Hypnotics and Sedatives / pharmacology*
Middle Aged
Phenobarbital / pharmacology*
Promethazine / pharmacology*
Pyridines / pharmacology*
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Pyridines; 50-06-6/Phenobarbital; 60-87-7/Promethazine; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of phenylethanolamine N-methyltransferase inhibitor, CGS19281A, on the alpha-2-adrenoceptor f...
Next Document:  Pharmacoelectroencephalographic profile of befloxatone, a new reversible MAO-A inhibitor, in healthy...