Document Detail

Mood disorders in the psychoneurologic borderland: three cases of responsiveness to carbamazepine.
MedLine Citation:
PMID:  2492164     Owner:  NLM     Status:  MEDLINE    
Three patients with affective disorders with psychotic features were refractory to various combinations of psychotropic agents (antipsychotics, antidepressants, and lithium). Closer scrutiny revealed a seizure history in two patients and unusual neuropsychiatric features in the third patient. Subsequent substitution of carbamazepine for the antipsychotic resulted in control of the patients' psychoses. The authors describe clinical features that may identify the patient who may respond to carbamazepine. The mechanism of carbamazepine's psychotropic effects through its hypothesized ability to inhibit limbic system kindling is discussed. The case reports emphasize the need for careful neuropsychiatric assessment of patients who are refractory to conventional treatments.
A J Kessler; N E Barklage; J W Jefferson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  146     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-13     Completed Date:  1989-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-3     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Wisconsin Medical School, Madison 53792.
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MeSH Terms
Anticonvulsants / therapeutic use
Bipolar Disorder / drug therapy*
Carbamazepine / therapeutic use*
Delirium, Dementia, Amnestic, Cognitive Disorders / drug therapy*
Depressive Disorder / drug therapy*
Drug Therapy, Combination
Epilepsy, Temporal Lobe / complications*,  drug therapy
Epilepsy, Tonic-Clonic / complications*,  drug therapy
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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