| Mood Problems Increase the Risk of Mortality in Patients With Lacunar Infarcts: the SMART-MR Study. | |
| | |
MedLine Citation:
|
PMID: 22434917 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective:A relationship between depression and mortality has been well established, but underlying mechanisms remain unclear. We investigated the influence of cerebral small vessel disease (CSVD), characterized by white matter lesions (WMLs) and lacunar infarcts, on the relationship between mood mortality during 6 years follow-up.Methods:Mood problems were assessed with the mental component summary of the 36-item Short-Form Medical Outcomes Study in 1110 patients with symptomatic atherosclerotic disease (mean age 59 years). Volumetric WML estimates were obtained with 1.5-T magnetic resonance imaging; lacunar infarcts were scored visually. Cox regression models were adjusted for age, sex, vascular risk, physical functioning, antidepressants and infarcts. We adjusted for CSVD to examine whether it may be an intermediate or confounding factor. Second, we added interaction terms to investigate whether associations differed between patients with CSVD (absent/present).Results:Patients in the lowest quartile of mental functioning, representing most severe mood problems, were at higher, although not significant, risk of death (hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 0.94-2.30) compared with patients in higher quartiles. Adjustment for CSVD did not change this association. Lacunar infarcts, not WML, modified the association of mood problems with mortality (p value for interaction = .01); mood problems strongly increased the risk of mortality in patients with lacunar infarcts (HR = 2.75, 95% CI = 1.41-5.38) but not in those without it (HR = 0.78, 95% CI = 0.39-1.57).Conclusions:Patients with lacunar infarcts may be especially vulnerable for the effect of mood problems on mortality. |
| | |
Authors:
|
Anne M Grool; Yolanda van der Graaf; Willem P Th M Mali; Theo D Witkamp; Koen L Vincken; Mirjam I Geerlings; |
Related Documents
:
|
15877627 - An unusual accessory pathway: anteroseptal to ventricular outflow region connection. 9474467 - Torsade de pointes secondary to d,l-sotalol after catheter ablation of incessant atriov... 2466257 - Advances in catheter ablation use of unipolar electrograms. 15902797 - Myocardial ischemia as a result of severe benzodiazepine and opioid withdrawal. 20435847 - Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone syst... 19008477 - Cardiac neural crest expression of hand2 regulates outflow and second heart field devel... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-20 |
Journal Detail:
|
Title: Psychosomatic medicine Volume: - ISSN: 1534-7796 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Julius Center for Health Sciences and Primary Care (A.M.G., Y.v.d.G., M.I.G.), Department of Radiology (W.P.T.M.M., T.D.W.), and Image Sciences Institute (K.L.V.), University Medical Center Utrecht, Utrecht, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combining psychosocial data to improve prediction of cardiovascular disease risk factors and events:...
Next Document: Depression in premenopausal women with HSDD: baseline findings from the HSDD Registry for Women.