Document Detail

Month of birth as a risk factor for narcolepsy.
MedLine Citation:
PMID:  14572117     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: A loss of hypocretin neurons has been observed in human narcolepsy; however, the cause of this disorder is still unknown. While family history and genetic factors are important individual risk factors for narcolepsy, environmental factors also contribute to the pathogenesis of the disease. The aim of the study was to find out whether there is a seasonality of month of birth in narcoleptic patients. DESIGN: Diagnosis of narcolepsy with cataplexy was based on International Classification of Sleep Disorders criteria with clinical, standard polysomnographic, and Multiple Sleep Latency Test features. PATIENTS AND SETTING: The birth dates of 886 patients with a clear-cut diagnosis of narcolepsy with cataplexy from 3 large narcolepsy databases (352 from Montpellier-France, 157 from Montreal-Canada, and 377 from Stanford-United States of America) were compared with those of 35,160,522 subjects from the general population. MEASUREMENTS AND RESULTS: Patients with narcolepsy had a significantly different seasonality of month of birth compared to that of the general population. The monthly distribution of birth yielded a peak in March with a maximal odds ratio at 1.45 and a trough in September with a minimal odds ratio at 0.63. No gender or country of origin differences were observed. CONCLUSIONS: A birth seasonality in the development of narcolepsy suggests the presence of environmental factors acting in combination with genetic factors during the fetal or perinatal period, in terms of an autoimmune process targeting the hypocretin system.
Yves Dauvilliers; Bertrand Carlander; Nicolas Molinari; Alex Desautels; Michele Okun; Mehdi Tafti; Jacques Montplaisir; Emmanuel Mignot; Michel Billiard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sleep     Volume:  26     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2004-02-17     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-5     Citation Subset:  IM    
Service de Neurologie B, Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac Montpellier, France.
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MeSH Terms
Birth Rate
Brain / metabolism
Carrier Proteins / metabolism
Embryonic and Fetal Development
Intracellular Signaling Peptides and Proteins*
Narcolepsy / diagnosis*,  epidemiology,  metabolism
Neurons / metabolism
Neuropeptides / metabolism
Polysomnography / methods
Risk Factors
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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