Document Detail


Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): a preliminary report.
MedLine Citation:
PMID:  20478636     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Chronic obstructive pulmonary disease (COPD) is an alteration in which ventilatory function, exercise capacity and health status of patients progressively decline and it is characterized by an increase of inflammatory cytokines such as TNF-α, LTB4, IL-8, etc. In this study we considered twenty patients (15 males and 5 females; mean age: 72.8 ± 6.3) with stable COPD. All patients were performed evaluation of psychological stress at enrollment and were treated with leukotriene receptor antagonists (montelukast tablets) 10mg/day for 12 months. After 12 months we observed a significant decrease of serum levels of LTB4, IL-8 and also a decrease of the number of outpatient clinic visits, of the number of hospitalizations and of the duration of hospitalization.
Authors:
Nicolò Gueli; Walter Verrusio; Adele Linguanti; Wladimiro De Santis; Nicoletta Canitano; Flora Ippoliti; Vincenzo Marigliano; Mauro Cacciafesta
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Publication Detail:
Type:  Journal Article     Date:  2010-05-15
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  52     ISSN:  1872-6976     ISO Abbreviation:  Arch Gerontol Geriatr     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2010-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e36-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Aging Science, Policlinico Umberto I, Sapienza University of Rome, viale del Policlinico, 155, I-00161 Roma, Italy. nicolo.gueli@uniroma1.it
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