| Montelukast prevents vascular endothelial dysfunction from internal combustion exhaust inhalation during exercise. | |
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MedLine Citation:
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PMID: 20462392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Associations between high particulate matter (PM) pollution and increased morbidity and mortality from coronary heart disease have been identified. This study assessed leukotriene (LT) participation in PM-induced vascular endothelial dysfunction. Ten healthy males exercised 4 times for 30 min in both high PM (550,286 +/- 42,004 particles x cm(-3)) and low PM (4571 +/- 1922 particles x cm(-3)) after ingesting placebo (PL) or 10 mg montelukast (MK; half-life 3-6 h), a leukotriene receptor antagonist. Brachial artery flow-mediated dilation (FMD) was measured pre- and 30 min, 4 h, 24 h post-exercise. No basal brachial artery vascoconstriction was evident from high PM exercise. High PM blunted FMD, whereas high PM MK, low PM PL, and low PM MK demonstrated normal FMD (p < .003). Change in FMD (pre- to post-exercise) for high PM PL was different than for high PM MK, low PM PL, and low PM MK at 30 min post-exercise (p < .007). At 4 h, high PM MK FMD blunting increased (p = .1). At 24 h, high PM FMD blunting persisted (p < .05); no difference was observed between high PM PL or MK treatment, but was different that low PM PL/MK treatments (p < .05). MK blocked high PM post-exercise FMD blunting and maintained normal response, suggesting that leukotrienes are involved in PM-initiated vascular endothelial dysfunction. |
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Authors:
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Kenneth W Rundell; Michelle D Steigerwald; Michelle Z Fisk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inhalation toxicology Volume: 22 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 754-9 Citation Subset: IM |
Affiliation:
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Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania 18509, USA. rundell@marywood.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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pharmacology* Air Pollutants / toxicity* Brachial Artery / drug effects, physiopathology Dose-Response Relationship, Drug Double-Blind Method Exercise Test Humans Leukotriene Antagonists / pharmacology* Male Microcirculation / drug effects Oxygen Consumption Quinolines / pharmacology* Regional Blood Flow / drug effects Vasoconstriction / drug effects* Vasodilation / drug effects* Vehicle Emissions / toxicity* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Air Pollutants; 0/Leukotriene Antagonists; 0/Quinolines; 0/Vehicle Emissions; 158966-92-8/montelukast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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