Document Detail

Montelukast prevents vascular endothelial dysfunction from internal combustion exhaust inhalation during exercise.
MedLine Citation:
PMID:  20462392     Owner:  NLM     Status:  MEDLINE    
Associations between high particulate matter (PM) pollution and increased morbidity and mortality from coronary heart disease have been identified. This study assessed leukotriene (LT) participation in PM-induced vascular endothelial dysfunction. Ten healthy males exercised 4 times for 30 min in both high PM (550,286 +/- 42,004 particles x cm(-3)) and low PM (4571 +/- 1922 particles x cm(-3)) after ingesting placebo (PL) or 10 mg montelukast (MK; half-life 3-6 h), a leukotriene receptor antagonist. Brachial artery flow-mediated dilation (FMD) was measured pre- and 30 min, 4 h, 24 h post-exercise. No basal brachial artery vascoconstriction was evident from high PM exercise. High PM blunted FMD, whereas high PM MK, low PM PL, and low PM MK demonstrated normal FMD (p < .003). Change in FMD (pre- to post-exercise) for high PM PL was different than for high PM MK, low PM PL, and low PM MK at 30 min post-exercise (p < .007). At 4 h, high PM MK FMD blunting increased (p = .1). At 24 h, high PM FMD blunting persisted (p < .05); no difference was observed between high PM PL or MK treatment, but was different that low PM PL/MK treatments (p < .05). MK blocked high PM post-exercise FMD blunting and maintained normal response, suggesting that leukotrienes are involved in PM-initiated vascular endothelial dysfunction.
Kenneth W Rundell; Michelle D Steigerwald; Michelle Z Fisk
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inhalation toxicology     Volume:  22     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  754-9     Citation Subset:  IM    
Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania 18509, USA.
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MeSH Terms
Acetates / pharmacology*
Air Pollutants / toxicity*
Brachial Artery / drug effects,  physiopathology
Dose-Response Relationship, Drug
Double-Blind Method
Exercise Test
Leukotriene Antagonists / pharmacology*
Microcirculation / drug effects
Oxygen Consumption
Quinolines / pharmacology*
Regional Blood Flow / drug effects
Vasoconstriction / drug effects*
Vasodilation / drug effects*
Vehicle Emissions / toxicity*
Young Adult
Reg. No./Substance:
0/Acetates; 0/Air Pollutants; 0/Leukotriene Antagonists; 0/Quinolines; 0/Vehicle Emissions; 158966-92-8/montelukast

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