| Montelukast has no ergogenic effect on cycle ergometry in cold temperature. | |
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MedLine Citation:
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PMID: 15514496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the effects of a single 10-mg dose of ML on physical performance in EIB- and EIB+ athletes. METHODS: Twenty-four male college ice hockey players performed two 6-min maximal work accumulation bouts on an electronically braked cycle ergometer in subfreezing conditions (-2.5 +/- 0.4 degrees C) 6-8 h after either ML or placebo (PL) to obtain total work accumulated (kJ); subjects were evaluated for EIB after each exercise trial. RESULTS: Eight (33%) subjects were identified as EIB+ (23.5 +/- 13.35% fall in FEV1); 16 were EIB- (1.8 +/- 3.03% fall in FEV1). ML provided an approximately 50% protection against postexercise fall in FEV1. No significant differences in kJ were found between PL and ML trials for pooled subjects (95.3 +/- 13.69 and 94.8 +/- 13.27 kJ, respectively), EIB- subjects (99.6 +/- 13.26 and 99.0 +/- 11.81 kJ, respectively), or EIB+ subjects (86.8 +/- 10.67 and 86.5 +/- 12.72 kJ, respectively). Total work accumulated for EIB- subjects was significantly greater than for EIB+ subjects for both PL and ML (P < 0.05). CONCLUSION: A single 10-mg dose of ML had no ergogenic effect for EIB- and EIB+ subjects performing short-duration high-intensity exercise in subfreezing temperature, supporting the use of ML as EIB prophylaxis during international sport competition. |
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Authors:
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Kenneth W Rundell; Barry A Spiering; Jennifer M Baumann; Tina M Evans |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 36 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-29 Completed Date: 2005-03-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1847-51 Citation Subset: IM; S |
Affiliation:
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Human Performance Laboratory, Keith J. O'Neill Center for Healthy Families, Marywood University, Scranton, PA 18509, USA. rundell@marywood.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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pharmacology* Adult Anti-Asthmatic Agents / pharmacology* Cold Temperature* Cross-Over Studies Double-Blind Method Exercise / physiology* Exercise Test* Hockey / physiology Humans Lung / drug effects Male Quinolines / pharmacology* Respiratory Function Tests Task Performance and Analysis |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Anti-Asthmatic Agents; 0/Quinolines; 158966-92-8/montelukast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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