| Montelukast as a treatment modality for eosinophilic gastroenteritis. | |
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MedLine Citation:
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PMID: 22319970 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Eosinophilic Gastroenteritis (EG) is a rare condition, caused by eosinophilic inflammatory infiltrates in the gastrointestinal tract. It is usually treated successfully with systemic glucocorticoids. Because of frequent relapses, however, there is need for alternatives. We describe a 38-year old man with steroid-dependent EG, who was successfully treated with montelukast, a leukotriene receptor antagonist. It inhibits leukotriene D4, an important cytokine in the inflammatory cascade. Although montelukast could not replace steroid therapy, it acted as a steroid sparing agent in our patient. Review of the literature shows that montelukast is efficient in the treatment of EG in a part of the patients. The low cost, the low number of side effects and its efficiency make it an interesting alternative in relapsing or steroid dependent EG. There is need for multicentric studies regarding the treatment of EG. |
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Authors:
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N De Maeyer; A-M Kochuyt; W Van Moerkercke; M Hiele |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 74 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 570-5 Citation Subset: IM |
Affiliation:
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Department of internal medicine, UZ Leuven, Belgium. nikolaas.demaeyer@gmail.com |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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