Document Detail

Montelukast as a treatment modality for eosinophilic gastroenteritis.
MedLine Citation:
PMID:  22319970     Owner:  NLM     Status:  In-Process    
Eosinophilic Gastroenteritis (EG) is a rare condition, caused by eosinophilic inflammatory infiltrates in the gastrointestinal tract. It is usually treated successfully with systemic glucocorticoids. Because of frequent relapses, however, there is need for alternatives. We describe a 38-year old man with steroid-dependent EG, who was successfully treated with montelukast, a leukotriene receptor antagonist. It inhibits leukotriene D4, an important cytokine in the inflammatory cascade. Although montelukast could not replace steroid therapy, it acted as a steroid sparing agent in our patient. Review of the literature shows that montelukast is efficient in the treatment of EG in a part of the patients. The low cost, the low number of side effects and its efficiency make it an interesting alternative in relapsing or steroid dependent EG. There is need for multicentric studies regarding the treatment of EG.
N De Maeyer; A-M Kochuyt; W Van Moerkercke; M Hiele
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta gastro-enterologica Belgica     Volume:  74     ISSN:  0001-5644     ISO Abbreviation:  Acta Gastroenterol. Belg.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0414075     Medline TA:  Acta Gastroenterol Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  570-5     Citation Subset:  IM    
Department of internal medicine, UZ Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Delayed liver metastasis of a meningeal solitary fibrous tumor.
Next Document:  Hepatic rhabdomyosarcoma in an adult: a rare primary malignant liver tumor. Case report and literatu...