Document Detail


Montelukast. No current use for asthma.
MedLine Citation:
PMID:  10660791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Montelukast (Singulair), an antiasthma drug belonging to the leukotriene antagonist family, has two indications: as adjunctive treatment for mild-to-moderate chronic asthma when regular inhaled steroid therapy and short-acting inhaled beta2 stimulants "on demand" are inadequate; and in prevention of effort-induced asthma. The clinical file on montelukast contains no methodologically acceptable comparisons with reference treatments. Several placebo-controlled trials have shown the efficacy of montelukast, with improvement in clinical scores and respiratory function tests in those with chronic asthma and prevention of effort-induced asthma. For chronic asthma, montelukast has not been compared with oral or inhaled long-acting beta2 stimulants or with sustained-release theophylline in patients inadequately controlled by steroid therapy. For effort-induced asthma, only two trials have compared montelukast with salmeterol. On the basis of preliminary results, the authors of both studies concluded that montelukast was superior. Clinical trials showed no clear difference in the frequency of side effects in patients taking montelukast and patients taking placebo. Montelukast, however, might be associated with Churg-Strauss syndrome in rare cases. Montelukast is expensive.
Authors:
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  46     ISSN:  0008-350X     ISO Abbreviation:  Can Fam Physician     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-23     Completed Date:  2000-02-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  CANADA    
Other Details:
Languages:  eng; fre     Pagination:  86-99     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetates / economics,  pharmacology,  therapeutic use*
Administration, Inhalation
Anti-Asthmatic Agents / economics,  pharmacology,  therapeutic use*
Asthma / drug therapy*
Chronic Disease
Drug Costs
Humans
Quinolines / economics,  pharmacology,  therapeutic use*
Steroids / therapeutic use
Chemical
Reg. No./Substance:
0/Acetates; 0/Anti-Asthmatic Agents; 0/Quinolines; 0/Steroids; 158966-92-8/montelukast
Comments/Corrections
Comment In:
Can Fam Physician. 2000 Jun;46:1262-3   [PMID:  10907561 ]
Can Fam Physician. 2000 Jun;46:1263-4   [PMID:  10907562 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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