| Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides. | |
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MedLine Citation:
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PMID: 20393237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A hybrid Monte Carlo transport scheme combining event-by-event and condensed-history simulation with a full account of energy-loss straggling was used to study the dosimetric characteristics of the Auger-emitting radionuclides 67Ga, 99mTc, 111In, 123I, 125I and 201Tl at the single-cell level. The influence of the intracellular localization of the Auger radionuclide upon cellular S-values, radial dose rate profiles and dose-volume-histograms (DVHs) was investigated. For the case where the radiopharmaceutical was either internalized into the cytoplasm or remained bound onto the cell surface (non-internalized), the dose to the cell nucleus was found to differ significantly from the MIRD values and other published data. In this case, the assumption of a homogeneous distribution throughout the cell is shown to significantly overestimate the nuclear dose. A dosimetric case study relevant to the radioimmunotherapy of single lymphoma B-cells with 125I and 123I is presented. |
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Authors:
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C Bousis; D Emfietzoglou; P Hadjidoukas; H Nikjoo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-14 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 55 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 2555-72 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, University of Ioannina, Ioannina 45110, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal Cell Line, Tumor Cell Nucleus / radiation effects Electrons* Humans Lymphoma, B-Cell / pathology, radiotherapy Monte Carlo Method* Radiation Dosage Radioisotopes / therapeutic use* Radiometry / methods* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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