Document Detail

'Monster cell' melanoma with pulmonary metastasis and cyclin D1 amplification.
MedLine Citation:
PMID:  23278726     Owner:  NLM     Status:  In-Data-Review    
Markedly pleomorphic epithelioid cells with high mitotic activity, giant cell formation, very large atypical nuclei, multiple nucleoli and abundant cytoplasm characterize 'monster' cells and may indicate aggressive tumor behavior. Very rare reports of melanomas comprised of 'monster cells' or cells with comparable histomorphological features, found in tissue samples from skin, lymph nodes, CNS, oral cavity and ileum have been published in the literature. This case is the first such description in the lung, and it is characterized with a battery of immunohistochemical stains; BRAF mutation status was negative, and fluorescence in situ hybridization analysis revealed increased copy number gains in 11q (cyclin D1), which is associated with poor prognosis in melanoma. The presence of monster cells in melanoma was associated with aggressive behavior in the reported patient.
Elena B Hawryluk; Johanna L Baran; Pedram Gerami; Alireza Sepehr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  40     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons A/S.
Department of Dermatology, Harvard Medical School, Boston, MA, USA.
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