| Monozygotic twins discordant for trisomy 13: counselling and management issues. | |
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MedLine Citation:
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PMID: 22842802 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The diagnosis and management of a heterokaryotypic monochorionic pregnancy, in which one of twins had trisomy 13, is presented. Monozygosity and discordant karyotypes were confirmed by amniocentesis of both the sacs. Radiofrequency ablation of the trisomic twin was successfully performed at 18-weeks gestation and the pregnancy ended at term with the birth of a healthy girl who remains well on follow-up at 12 months of age. We reiterate the importance of early amniocentesis of both the sacs in the presence of discordant fetal abnormalities and consideration of selective fetal termination to optimise the outcome of heterokaryotypic monochorionic twin pregnancies. |
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Authors:
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A Dixit; G Tanteles; K Ocraft; A McEwan; A Sarkar |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 32 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 639-41 Citation Subset: IM |
Affiliation:
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Department of Clinical Genetics, Nottingham City Hospital, Nottingham, UK. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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