Document Detail

Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation.
MedLine Citation:
PMID:  11387303     Owner:  NLM     Status:  MEDLINE    
A 3 year retrospective analysis was conducted of pregnancies achieved after various assisted reproductive treatment modalities in our infertility practice, to calculate and compare the rates of monozygotic twinning (MZT). A total of 731 pregnancies achieved after various assisted reproduction treatments were reviewed. Gonadotrophin therapy for induction of ovulation and controlled ovarian hyperstimulation (COH) yielded 129 clinical pregnancies. Conventional IVF yielded 139 pregnancies. IVF and intracytoplasmic sperm injection (ICSI) with or without assisted hatching (AH) yielded 463 pregnancies, all during the same time period. The rates of multiple pregnancy (monozygotic and dizygotic) twins and triplets were recorded. MZT was found in 1.5% of ovulation induction or COH pregnancies (2/129). The incidence of MZT after conventional IVF was 0.72% (1/139). After IVF-ICSI/AH, MZT was found in 0.86% (4/463). The overall rate of MZT was 0.95% (7/731). Five cases were dizygotic triplets and two cases were monozygotic twins. We found the rate of MZT after assisted reproduction treatment increased more than two-fold over the background rate in the general population. Dizygotic triplets were found more often than monozygotic twins. The rate of MZT was consistently increased, irrespective of treatment modality or micromanipulation. This may signify that the aetiology of increased MZT after assisted reproduction is the gonadotrophin treatment rather than in-vitro conditions, micromanipulation, or multiple embryo transfer.
M Schachter; A Raziel; S Friedler; D Strassburger; O Bern; R Ron-El
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  16     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-01     Completed Date:  2001-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1264-9     Citation Subset:  IM    
IVF and Infertility Unit, Assaf Harofeh Medical Center, Zerifin, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage
Embryo Transfer
Estradiol / blood
Fertilization in Vitro
Ovulation Induction
Pregnancy, Multiple
Reproductive Techniques*
Sperm Injections, Intracytoplasmic
Twins, Monozygotic*
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol

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