Document Detail

Monozygotic triplet pregnancies after single blastocyst transfer: two cases and literature review.
MedLine Citation:
PMID:  20638341     Owner:  NLM     Status:  MEDLINE    
Following IVF, single blastocyst transfer has been thought to reduce the risks of high-order multiple pregnancies. This is a report of two cases of monozygotic triplet pregnancies after single blastocyst transfer and a review of the current concepts of the pathogenesis of multiple monozygotic pregnancies as well as the options for managing these high-risk pregnancies. Both cases were reduced to a twin pregnancy by selective cord coagulation at 15-16 weeks. Whereas one patient had uneventful pregnancy until labour was induced for growth arrest and cord Doppler abnormalities in one twin, the other developed a severe twin-to-twin transfusion syndrome which required fetoscopic laser surgery at 21 weeks. In both cases, healthy twins were delivered by Caesarean section at 34.5 and 34 weeks, respectively. As the predictors of their occurrence are not fully understood, patients should be informed of the risks of monozygotic pregnancies after single blastocyst transfer.
Lionel Dessolle; Dalila Allaoua; Thomas Fréour; Claudine Le Vaillant; Henri-Jean Philippe; Miguel Jean; Paul Barrière
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-04-24
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  21     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-16     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Service de biologie et médecine de la reproduction, Centre Hospitalier Universitaire de Nantes, 38, Bd Jean Monnet, 44093 Nantes Cedex 1, France.
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MeSH Terms
Embryo Transfer / adverse effects
Fetofetal Transfusion* / etiology
Infant, Newborn
Pregnancy Reduction, Multifetal
Pregnancy, Multiple* / genetics
Risk Factors
Single Embryo Transfer* / adverse effects
Triplets* / genetics
Twinning, Monozygotic* / genetics

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