Document Detail

Monozygotic multiple gestation after intracytoplasmic sperm injection and preimplantation genetic diagnosis.
MedLine Citation:
PMID:  19819442     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a possible association between intracytoplasmic sperm injection (ICSI)-preimplantation genetic diagnosis (PGD) and monozygotic multiple gestation. DESIGN: Small case series. SETTING: In vitro fertilization unit in an academic medical center. PATIENT(S): Three patients were treated with ICSI-PGD for sexing as well as selection against a known translocation. INTERVENTION(S): Transfer of day 4 embryos to the uterus. MAIN OUTCOME MEASURE(S): Clinical pregnancy. RESULT(S): Two pairs of monozygotic twins and a triplet pregnancy. CONCLUSION(S): Repeated manipulation of the zona pellucida as well as extended embryo culture during ICSI-PGD treatments may result in monozygotic twin and triplet pregnancies.
Ronit Haimov-Kochman; Hagit Daum; Francine Lossos; Einat Aizenman; Marion Werner; Simcha Yagel; Neri Laufer; Alex Simon; Arye Hurwitz
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-10-12
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2037.e11-7     Citation Subset:  IM    
IVF Unit, Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
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MeSH Terms
Embryo Culture Techniques
Embryo Transfer / adverse effects*
Fertilization in Vitro
Infant, Newborn
Pregnancy Outcome
Pregnancy Reduction, Multifetal
Preimplantation Diagnosis*
Sperm Injections, Intracytoplasmic / adverse effects*
Twins, Monozygotic*
Zona Pellucida

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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