| Monounsaturated, trans, and saturated Fatty acids and cognitive decline in women. | |
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MedLine Citation:
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PMID: 21568955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To prospectively assess effects of select dietary fats on cognitive decline. DESIGN: Prospective observational; 3-year follow-up. SETTING: Northwestern University. PARTICIPANTS: Four hundred eighty-two women aged 60 and older who participated in the Women's Health Initiative (WHI) Observational Study or in the control group of the WHI Diet Modification arm. MEASUREMENTS: Dietary intake from a validated food frequency questionnaire (FFQ) administered twice (mean 2.7 years apart) before baseline cognitive assessment (mean 2.9 years after second FFQ) was averaged. Testing of memory, vision, executive function, language, and attention was performed twice, 3 years apart. A global Z-score was created for both time points by averaging all Z-scores for each participant, and global cognitive change was defined as the difference between follow-up and baseline Z-scores. RESULTS: Median intake of saturated fat (SFA), trans-fat, (TFA), dietary cholesterol (DC), and monounsaturated fat (MUFA) was 18.53, 3.45, 0.201, and 19.39 g/d, respectively. There were no associations between degree of cognitive decline and intake of SFA (P=.69), TFA (P=.54), or DC (P=.64) after adjusting for baseline cognition, total energy intake, age, education, reading ability, apolipoprotein E ɛ4 allele, body mass index, estrogen and beta-blocker use, and intake of caffeine and other fatty acids. In contrast, MUFA intake was associated with lower cognitive decline in fully adjusted linear regression models, with mean decline (standard error) of 0.21 (0.05) in the lowest and 0.05 (0.05) in the highest quartiles (P=.02). This effect of MUFA intake was primarily in the visual and memory domains (P=.03 for both). CONCLUSION: Greater intake of SFA, TFA, and DC was not associated with cognitive decline, whereas greater MUFA intake was associated with less cognitive decline. |
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Authors:
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Asghar Z Naqvi; Brian Harty; Kenneth J Mukamal; Anne M Stoddard; Mara Vitolins; Julie E Dunn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 59 ISSN: 1532-5415 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-16 Completed Date: 2011-07-26 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 837-43 Citation Subset: IM |
Copyright Information:
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© 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society. |
Affiliation:
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Harvard Medical School, Boston, Massachusetts, USA. anaqvi@bidmc.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cognition Disorders / chemically induced*, epidemiology Diet Surveys Fatty Acids / adverse effects* Fatty Acids, Monounsaturated / adverse effects* Female Humans Illinois / epidemiology Least-Squares Analysis Linear Models Middle Aged Prospective Studies Risk Factors Trans Fatty Acids / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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N01WH22110/WH/WHI NIH HHS; N01WH24152/WH/WHI NIH HHS; N01WH32100-2/WH/WHI NIH HHS; N01WH32105-6/WH/WHI NIH HHS; N01WH32108-9/WH/WHI NIH HHS; N01WH32111-13/WH/WHI NIH HHS; N01WH32115/WH/WHI NIH HHS; N01WH32118-32119/WH/WHI NIH HHS; N01WH32122/WH/WHI NIH HHS; N01WH42107-26/WH/WHI NIH HHS; N01WH42129-32/WH/WHI NIH HHS; N01WH44221/WH/WHI NIH HHS; R01 AG018695-01A1/AG/NIA NIH HHS; R01 AG018695-01A1/AG/NIA NIH HHS; T32 AT000051/AT/NCCAM NIH HHS; T32 AT000051-05/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Trans Fatty Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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