| Monotherapy with HMG-CoA reductase inhibitors and secondary prevention in coronary artery disease. | |
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MedLine Citation:
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PMID: 8874986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although thrombolytic drugs, percutaneous transluminal coronary angioplasty, and coronary artery bypass grafting have provided major advances in the treatment of coronary artery disease, the use of lipid-lowering drugs for secondary prevention has significantly reduced cardiovascular events in the population with coronary artery disease. Secondary prevention trials using HMG-CoA reductase inhibitors include the Familial Atherosclerosis Treatment Study (FATS), the Monitored Atherosclerosis Regression Study (MARS), the Canadian Coronary Atherosclerosis Intervention Trial (CCAIT), the Asymptomatic Carotid Artery Progression Study (ACAPS), the Multi Anti-Atheroma Study (MAAS), the Scandinavian Simvastatin Survival Study (4S), the Pravastatin Limitation of Atherosclerosis in Coronary Arteries (PLAC I), the Regression Growth Evaluation Statin Study (REGRESS), the Pravastatin Multinational Study, and the Pravastatin, Lipids, and Atherosclerosis in Carotids (PLAC II). Mean changes from baseline of lipid fractions in these trials included: total cholesterol 18 to 35% reduction; low-density lipoprotein (LDL) cholesterol 26 to 46% reduction; high-density lipoprotein (HDL) cholesterol 5 to 15% increase; and triglyceride 7 to 22% reduction. Angiographic regression or lack of progression was statistically demonstrated in the FATS, MARS, CCAIT, MAAS, PLAC I, and REGRESS trials. Cardiovascular events decreased 25 to 92% in all trials, and there was a significant reduction in both cardiovascular and total mortality in the 4S. The greater reduction in cardiovascular events than in anatomic changes suggests that the HMG-CoA reductase inhibitors stabilized the surface of plaques. Monotherapy with HMG-CoA reductase inhibitors provides the clinical opportunity to modify the natural history of coronary artery disease. |
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Authors:
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C E Rackley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical cardiology Volume: 19 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-01-16 Completed Date: 1997-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 683-9 Citation Subset: IM |
Affiliation:
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Lipid Disorder Center, Georgetown University Medical Center, Washington, D.C. 20007-2196, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carotid Artery Diseases
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drug therapy Clinical Trials as Topic Coronary Artery Disease / drug therapy Coronary Disease / complications, drug therapy*, physiopathology Enzyme Inhibitors / therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Lovastatin / analogs & derivatives, therapeutic use Pravastatin / therapeutic use Simvastatin |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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