Document Detail

Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans.
MedLine Citation:
PMID:  21030612     Owner:  NLM     Status:  MEDLINE    
The consumption of monosodium glutamate (MSG) is advocated to elicit physiological and metabolic effects, yet these effects have been poorly investigated directly in humans and in particular in the postprandial phase. Thirteen healthy adults were supplemented for 6 days with a nutritional dose of MSG (2 g) or sodium chloride (NaCl) as control, following a crossover design. On the 7th day, they underwent a complete postprandial examination for the 6 h following the ingestion of the same liquid standard meal (700 kcal, 20% of energy as [(15)N]protein, 50% as carbohydrate, and 30% as fat) supplemented with MSG or NaCl. Real-ultrasound measures of antral area indicated a significant increased distension for the 2 h following the meal supplemented with MSG vs. NaCl. This early postprandial phase was also associated with significantly increased levels of circulating leucine, isoleucine, valine, lysine, cysteine, alanine, tyrosine, and tryptophan after MSG compared with NaCl. No changes to the postprandial glucose, insulin, glucagon-like peptide (GLP)-1, and ghrelin were noted between MSG- and NaCl-supplemented meals. Subjective assessments of hunger and fullness were neither affected by MSG supplementation. Finally, the postprandial fate of dietary N was identical between dietary conditions. Our findings indicate that nutritional dose of MSG promoted greater postprandial elevations of several indispensable amino acids in plasma and induced gastric distension. Further work to elucidate the possible sparing effect of MSG on indispensable amino acid first-pass uptake in humans is warranted. This trial was registered at as NCT00862017.
Claire Boutry; Hideki Matsumoto; Gheorghe Airinei; Robert Benamouzig; Daniel Tomé; François Blachier; Cécile Bos
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-28
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  300     ISSN:  1522-1547     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G137-45     Citation Subset:  IM    
INRA, Research Center for Human Nutrition-IdF, UMR914, Paris, France.
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MeSH Terms
Amino Acids / blood*
Cross-Over Studies
Gastric Emptying / drug effects
Middle Aged
Postprandial Period / physiology
Pyloric Antrum / drug effects*
Sodium Glutamate / pharmacology*
Reg. No./Substance:
0/Amino Acids; 142-47-2/Sodium Glutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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