| Monophosphoryl lipid A adjuvant reverses a principal histologic parameter of formalin-inactivated respiratory syncytial virus vaccine-induced disease. | |
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MedLine Citation:
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PMID: 11228376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms by which administration of a formalin-inactivated respiratory syncytial virus vaccine resulted in enhanced disease among children after they later became naturally infected with the virus remains largely undefined. After immunization and live virus challenge, the cotton rat demonstrated the histopathologic marker of the enhanced disease, polymorphonuclear leukocyte infiltration of lung alveolar spaces. We now report that immunization with formalin-inactivated vaccine formulated with the adjuvant, 3-deacylated monophosphoryl lipid A, dramatically reduces or eliminates the polymorphonuclear leukocyte infiltration within the alveoli of cotton rats post-challenge. We suggest, that this or similar adjuvants may be beneficial components of candidate non-replicating respiratory syncytial virus vaccines, whose development has been hampered by safety concerns. |
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Authors:
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G A Prince; F Denamur; M Deschamps; N Garçon; J P Prieels; M Slaoui; C Thiriart; D D Porter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vaccine Volume: 19 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: England |
Other Details:
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Languages: eng Pagination: 2048-54 Citation Subset: IM |
Affiliation:
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Virion Systems Inc., Rockville, MD 20850, USA. gprince@erols.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage* Animals Child Female Formaldehyde Humans Lipid A / administration & dosage*, analogs & derivatives Male Pulmonary Alveoli / pathology Respiratory Syncytial Virus Infections / immunology, pathology, prevention & control Respiratory Syncytial Viruses / immunology* Safety Sigmodontinae Vaccines, Inactivated / adverse effects, toxicity Viral Vaccines / adverse effects*, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Lipid A; 0/Vaccines, Inactivated; 0/Viral Vaccines; 0/monophosphoryl lipid A; 50-00-0/Formaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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