Document Detail


Mononuclear leucocyte function in patients with lichen planus and cutaneous lupus erythematosus during chemotherapy with clofazimine.
MedLine Citation:
PMID:  2919338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitogen-induced transformation and the production of reactive oxidants by mononuclear leucocytes (MNLs) from patients with chronic dermatological disorders were investigated in vitro before and during the administration of the antimycobacterial/immunosuppressive agent clofazimine (200 mg 3 times weekly). Seven patients, 4 with lichen planus and 3 with cutaneous lupus erythematosus, were included in the study. Clofazimine administration did not influence the mitogen-induced proliferative responses of patients' MNLs. However, chemotherapy with this drug stimulated the production of reactive oxidants by MNLs. Since reactive oxidants are immunosuppressive it is possible that these effects may be involved in the pharmacotherapeutic activity of clofazimine.
Authors:
B M Zeis; E J Schulz; R Anderson; H H Kleeberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  75     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  161-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Clofazimine / pharmacology*
Female
Humans
Immunity, Cellular / drug effects
Leukocytes, Mononuclear / drug effects,  immunology*,  metabolism
Lichen Planus / immunology*
Lupus Erythematosus, Cutaneous / immunology*
Lupus Erythematosus, Discoid / immunology*
Lymphocyte Activation / drug effects*
Male
Oxidants, Photochemical / biosynthesis
Pilot Projects
Chemical
Reg. No./Substance:
0/Oxidants, Photochemical; D959AE5USF/Clofazimine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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