Document Detail

Monomeric methylmethacrylate (MMA) acts on the desheathed myelinated nerve and on the node of Ranvier.
MedLine Citation:
PMID:  304714     Owner:  NLM     Status:  MEDLINE    
The influence of monomeric methylmethacrylate (MMA) on resting and compound action potential of the isolated desheathed sciatic nerve of the frog (sucrose gap method) was determined. Above 10 mM there was a dose-dependent decrease of the compound action potential and a hyperpolarization of the membrane which was augmented with increasing MMA concentrations (4.1 mV +/- 0.2 S.E.M. after 50 mM MMA). The depolarization in low [Ca2+]0 solutions or with veratrine was reversed by MMA. The homologous ethyl, allyl and n-butyl esters were more effective than MMA, and the isobutyl ester less effective, whereas Na-methacrylate and methacrylamide showed no influence. Voltage clamp experiments on the node of Ranvier indicated that 50 mM MMA led to a decrease of the Na+ and K+ currents.
H G Böhling; U Borchard; H Drouin
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of toxicology     Volume:  38     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Calcium / pharmacology
Methylmethacrylates / pharmacology*
Myelin Sheath / physiology*
Potassium / pharmacology
Rana esculenta
Ranvier's Nodes / drug effects*
Sciatic Nerve / drug effects*
Sodium / physiology
Time Factors
Veratrine / pharmacology
Reg. No./Substance:
0/Methylmethacrylates; 62-59-9/Veratrine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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