| Monohydroxylated poly(3-hydroxyoctanoate) oligomers and its functionalized derivatives used as macroinitiators in the synthesis of degradable diblock copolyesters. | |
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MedLine Citation:
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PMID: 17338561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of a hydroxyl group at the end of poly(3-hydroxyoctanoate) oligomers, noted PHO oligomers, is required to prepare diblock copolymers with improved properties by ring-opening polymerization of cyclic monomer as epsilon-caprolactone. Several chemical methods such as basic hydrolysis, acid-catalyzed reaction with APTS, and methanolysis were used to prepare well-defined low molar masses PHO oligomers. The methanolysis reaction was allowed to proceed for 10-60 min to produce PHO oligomers with Mn values ranging from 20,000 to 800 g mol-1 with low polydispersity index. Detailed analysis of the MALDI-TOF mass spectra of the obtained oligomers has revealed the presence of linear structures bearing methyl ester on one side and hydroxyl end group on the other side. The same procedure was applied to poly(3-hydroxyoctanoate-co-3-hydroxyundecenoate), PHOU, a poly(3-hydroxyalkanoate) containing unsaturated units in its side chains. These oligomers were further used to initiate the polymerization of epsilon-caprolactone by varying the PHO (or PHOU) and PCL lengths. By copolymerization with epsilon-caprolactone, the properties of PHO or PHOU have been improved. The crystallinity of the obtained copolymers was modified by controlling the length of the two different blocks. The unsaturations in the side chains of the PHOU block were oxidized in acid carboxylic functions to obtain a novel artificial biopolyester. Moreover, degradation was followed to study the influence of carboxylic groups on the hydrolysis of the copolymers. |
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Authors:
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Laurianne Timbart; Estelle Renard; Martine Tessier; Valérie Langlois |
Publication Detail:
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Type: Journal Article Date: 2007-03-06 |
Journal Detail:
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Title: Biomacromolecules Volume: 8 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 1255-65 Citation Subset: IM |
Affiliation:
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Laboratoire de Recherche sur les Polymères, UMR 7581, Université Paris 12-Val de Marne, CNRS, 2 à 8 rue H. Dunant, 94 320 Thiais, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Macromolecular Substances
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chemistry* Molecular Structure Oxidation-Reduction Polyesters / chemical synthesis*, chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Macromolecular Substances; 0/Polyesters; 120659-38-3/poly(3-hydroxyoctanoic acid) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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