| Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225. | |
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MedLine Citation:
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PMID: 20651937 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage. |
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Authors:
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Xiaoyuan Chen; Min Ji; Darrell R Fisher; Chien M Wai |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Synlett : accounts and rapid communications in synthetic organic chemistry Volume: 11 ISSN: 0936-5214 ISO Abbreviation: - Publication Date: 1999 Sep |
Date Detail:
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Created Date: 2010-7-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203577 Medline TA: Synlett Country: - |
Other Details:
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Languages: ENG Pagination: 1784-1786 Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R21 EB001785-02//NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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