Document Detail


Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.
MedLine Citation:
PMID:  20651937     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.
Authors:
Xiaoyuan Chen; Min Ji; Darrell R Fisher; Chien M Wai
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Synlett : accounts and rapid communications in synthetic organic chemistry     Volume:  11     ISSN:  0936-5214     ISO Abbreviation:  -     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2010-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203577     Medline TA:  Synlett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1784-1786     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R21 EB001785-02//NIBIB NIH HHS

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