| Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. | |
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MedLine Citation:
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PMID: 20153259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-15 contributes to the immunopathogenesis of Celiac disease (CD). However, it is not clear how IL-15 affects APC that shape adaptive immune responses to the dietary antigen, gliadin. Using PBMC from healthy individuals, we show that monocytes differentiated with IL-15 (IL15-DC) produced IL-1beta, IL-6, IL-15, IL-23, TNFalpha and CCL20 in response to pepsin-trypsin digested gliadin (PTG) and activated contact-dependent Th17 and Th1 responses from autologous CD4(+) T cells. Lower concentrations of IL-15 augmented IFNgamma responses to PTG in PBMC from CD patients compared to controls. Thus, IL-15 supports Th17 and Th1 responses to a dietary antigen that is normally well-tolerated in healthy individuals by generating IL15-DC. These potentially pathogenic immune responses may result in CD patients and not healthy individuals as a consequence of IL-15 hypersensitivity. Therefore, genetic and/or environmental factors that control IL-15 expression and responsiveness in the intestine likely participate in the pathogenesis of CD. |
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Authors:
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Kristina M Harris; Alessio Fasano; Dean L Mann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 135 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-06-09 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 430-9 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Pathology Department, University of Maryland School of Medicine, Baltimore, MD, USA. kholt003@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Celiac Disease
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immunology*,
metabolism Cell Differentiation / immunology* Cell Separation Cells, Cultured Dendritic Cells / immunology, metabolism Flow Cytometry Gene Expression Regulation / immunology* Gliadin / immunology* Humans Interleukin-15 / biosynthesis, genetics, physiology* Interleukin-17 / biosynthesis* Lymphocyte Activation / immunology Monocytes / cytology, immunology* Th1 Cells / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK078699/DK/NIDDK NIH HHS; R21 DK078699-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-15; 0/Interleukin-17; 9007-90-3/Gliadin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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