Document Detail

Monocytes are progressively activated in the circulation of pregnant women.
MedLine Citation:
PMID:  12429709     Owner:  NLM     Status:  MEDLINE    
Pregnancy is characterized by the presence of generalized leukocyte activation. We used flow cytometry to investigate changes in phenotype and intracellular cytokines of circulating granulocytes, monocytes, and T lymphocytes of pregnant women during gestation. We report that peripheral circulation of pregnancy is characterized by an increased percentage of granulocytes and a decrease in lymphocytes. The proportion of monocytes remains stable throughout gestation; however, a progressive up-regulation of surface markers CD11a, CD54, and CD64 was detected. Monocytes also showed higher production of interleukin (IL)-12 and IL-1beta compared with the nonpregnant state, and granulocytes had greater potential to synthesize IL-8. All these changes were particularly marked in late gestation. T lymphocytes did not have any characteristics of the activated state and showed a decreased IL-6 production. These findings demonstrate that activation of maternal monocytes and granulocytes increases during pregnancy and support the idea that pregnancy results in an elevation of the innate immune system and suppression of the adaptive immune system.
Patrizia Luppi; Catherine Haluszczak; Dawn Betters; Craig A H Richard; Massimo Trucco; Julie A DeLoia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  72     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2002-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  874-84     Citation Subset:  IM    
Division of Immunogenetics Department of Pediatrics, Rangos Research Center, Children's Hospital of Pittsburgh, PA 15213, USA.
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MeSH Terms
Antibody Specificity
Cell Adhesion Molecules / metabolism
Cytokines / biosynthesis,  immunology
Flow Cytometry
Granulocytes / immunology
Leukocytes / classification
Monocytes / immunology*
Pregnancy / blood,  immunology*
Prospective Studies
T-Lymphocytes / immunology
Grant Support
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Cytokines
Comment In:
J Leukoc Biol. 2004 Feb;75(2):153-4; author reply 155-6   [PMID:  14694184 ]

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