Document Detail


Monocyte tissue factor activity in anticoagulant-treated patients.
MedLine Citation:
PMID:  6845276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tissue factor coagulant activity of peripheral blood monocytes was measured in 20 patients on long-term anticoagulant treatment with warfarin and in 21 healthy individuals. Contrary to expectations, tissue factor activity was not reduced in the warfarin-treated group and was, in fact, elevated in several patients. No relationship existed between the daily warfarin dose or the degree of prolongation of the prothrombin time and the monocyte tissue factor activity. These results indicate that monocyte tissue factor activity is not necessarily reduced to below normal levels with warfarin treatment.
Authors:
L R Zacharski; J R Beck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  29     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / drug therapy,  metabolism
Female
Humans
Male
Monocytes / drug effects*,  metabolism
Phytohemagglutinins / pharmacology
Prothrombin Time
Thromboplastin / metabolism*
Warfarin / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Phytohemagglutinins; 81-81-2/Warfarin; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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