Document Detail


Monocyte recruitment and foam cell formation in atherosclerosis.
MedLine Citation:
PMID:  16360317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of monocytes with activated endothelium are crucial events leading to atherosclerotic alteration of the arterial intima. In early atherosclerosis, monocytes migrate into the subendothelial layer of the intima where they differentiate into macrophages or dendritic cells. In the subendothelial space enriched with atherogenic lipoproteins, most macrophages transform into foam cells. Foam cells aggregate to form the atheromatous core and as this process progresses, the atheromatous centres of plaques become necrotic, consisting of lipids, cholesterol crystals and cell debris. This review highlights some aspects of monocyte recruitment and foam cell formation in atherosclerosis.
Authors:
Yuri V Bobryshev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-11-09
Journal Detail:
Title:  Micron (Oxford, England : 1993)     Volume:  37     ISSN:  0968-4328     ISO Abbreviation:  Micron     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312850     Medline TA:  Micron     Country:  England    
Other Details:
Languages:  eng     Pagination:  208-22     Citation Subset:  IM    
Affiliation:
Surgical Professorial Unit, St Vincent's Hospital, 234 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. y.bobryshev@unsw.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aorta / immunology
Arteries / immunology
Atherosclerosis / immunology*,  pathology
Cell Differentiation
Cell Movement
Dendritic Cells / immunology
Foam Cells / cytology,  immunology*
Humans
Lipoproteins / metabolism
Macrophages / immunology,  metabolism
Microscopy, Electron
Monocytes / cytology,  immunology*,  ultrastructure
Tunica Intima / immunology
Chemical
Reg. No./Substance:
0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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