Document Detail

Monocyte major histocompatibility complex class II expression in term and preterm labor.
MedLine Citation:
PMID:  18055729     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate how term and preterm labor (PTL) influence the balance between maternal proinflammatory and antiinflammatory responses as measured by expression of major histocompatibility complex (MHC) Class II on maternal monocytes and tumor necrosis factor-alpha (TNF-alpha) production by in vitro stimulation of whole blood by lipopolysaccharide (LPS). METHODS: Blood was taken from the following women (n=118): term elective cesarean delivery or in spontaneous labor, in premature labor, or with preterm premature rupture of the membranes (PROM) at less than 32 weeks, and gestation-matched reference group. Monocyte MHC Class II expression was measured by flow cytometry using a dual-staining technique. Plasma cytokine levels were assayed using a cytometric bead array system. In vitro whole blood stimulation with LPS was also performed, and cytokine production was measured. RESULTS: Term labor was associated with a fall in the percentage of monocytes expressing MHC Class II, compared with third trimester of pregnancy, P<.05 and a reduction in LPS-stimulated TNF-alpha production. This fall in MHC Class II was even more pronounced in PTL and preterm PROM groups compared with the reference group, P<.01. CONCLUSION: There was evidence of reduced expression of monocyte MHC Class II and LPS-stimulated TNF-alpha in term and preterm labor. This pattern of reduced MHC Class II expression and reduced TNF-alpha production is known as monocyte hyporesponsiveness or immune paresis. Detection of this state may provide insights into the maternal inflammatory status and be of use in the management of women with threatened PTL or preterm PROM. LEVEL OF EVIDENCE: II.
Jillian Lloyd; Meredith Allen; Mallika Azizia; Nigel Klein; Donald Peebles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  110     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-17     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1335-42     Citation Subset:  AIM; IM    
Institute for Women's Health, and Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, London, United Kingdom.
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MeSH Terms
Case-Control Studies
Fetal Membranes, Premature Rupture / blood,  immunology*,  metabolism
Gene Expression Profiling
Histocompatibility Antigens Class II / metabolism*
Macrophage Activation / physiology
Monocytes* / immunology,  metabolism
Obstetric Labor, Premature / blood,  immunology*,  metabolism
Pregnancy Trimester, Third
Prospective Studies
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 0/Tumor Necrosis Factor-alpha

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