Document Detail


Monocyte-derived dendritic cells: a potential target for therapy in multiple sclerosis (MS).
MedLine Citation:
PMID:  11207659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monocytes can differentiate into dendritic cells (DC), cells with a pivotal role in both protective immunity and tolerance. Defects in the maturation or function of DC may be important in the development of autoimmune disease. We sought to establish if there were differences in the cytokine (granulocyte-macrophage colony-stimulating factor and IL-4)-driven maturation of monocytes to DC in patients with MS and whether drugs used to treat MS affected this process in vitro. We have demonstrated that there is no defect in the ability of magnetic activated cell sorting (MACS)-purified monocytes from patients with MS to differentiate to DC, but equally they show no tendency to acquire a DC phenotype without exogenous cytokines. Interferon-beta1a prevents the acquisition of a full DC phenotype as determined by light and electron microscopy and by flow cytometry. Methylprednisolone not only prevents the development of monocyte-derived DC but totally redirects monocyte differentiation towards a macrophage phenotype. Evidence is evolving for a role for DC in central nervous system immunity, either within the brain or in cervical lymph nodes. The demonstrated effect of both drugs on monocyte differentiation may represent an important site for immune therapy in MS.
Authors:
M E Duddy; G Dickson; S A Hawkins; M A Armstrong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  123     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-04-05     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  280-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Queen's University Belfast, Belfast, UK. m.duddy@queens-belfast.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Differentiation / drug effects,  immunology
Cytokines / pharmacology,  therapeutic use
Dendritic Cells / immunology,  pathology*
Female
Humans
Immunotherapy
Male
Monocytes / immunology,  pathology*
Multiple Sclerosis / immunology,  pathology*,  therapy
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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