Document Detail


Monocyte count is an underlying marker of lacunar subtype of hypertensive small vessel disease.
MedLine Citation:
PMID:  18452544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In the hypertensive small vessel disease (HSVD), it remains unclear why some patients develop lacunar infarcts (LIs) whilst others develop deep intracerebral hemorrhages (dICHs). Inflammation might be related to LI, and leukocyte and monocyte counts are regarded as an inflammatory marker of ischemic stroke. OBJECTIVE: We investigated the relationship between leukocyte and monocyte counts determined in the first 24 h after stroke onset in HSVD patients. METHODS: We prospectively studied 236 patients with first acute stroke because of HSVD (129 LI and 107 dICH). We analyzed demographic data, vascular risk factors, and white blood cell count subtypes obtained in the first 24 h after stroke. RESULTS: The multivariate analysis showed that LI subtype of HSVD was correlated with hyperlipidemia (P < 0.0001), a higher monocyte count (P = 0.002), and showed a trend with current smoking (P = 0.051), whereas dICH subtype was correlated with low serum total cholesterol (P = 0.003), low serum triglycerides (P < 0.0001), and high neutrophil count (P = 0.050). CONCLUSIONS: In patients who developed HSVD-related stroke, high monocyte count, current smoking, and hyperlipidemia are prothrombotic factors related to LI, whereas low cholesterol and triglyceride values are related to dICH. Monocyte count might be an inflammatory risk marker for the occlusion of small vessels in hypertensive patients.
Authors:
M Gomis Cortina; A Rodríguez Campello; J Jiménez Conde; A Ois; A Voustianiouk; M J Téllez; E Cuadrado; J Roquer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-29
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  15     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Affiliation:
Stroke Unit, Neurology Department, Hospital del Mar, Departament de Medicina de la Universitat Autónoma de Barcelona, Barcelona, Spain. 92571@imas.imim.es
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Blood Vessels / pathology
Cerebral Hemorrhage / etiology*
Female
Humans
Hypertension / blood,  complications*,  pathology
Intracranial Arterial Diseases / blood,  complications*,  pathology
Leukocyte Count
Male
Monocytes*
Stroke / etiology*
Chemical
Reg. No./Substance:
0/Biological Markers

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