| Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. | |
| | |
MedLine Citation:
|
PMID: 9168785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Monocytes are activated during collateral artery growth in vivo, and monocyte chemotactic protein-1 (MCP-1) has been shown to be upregulated by shear stress in vitro. In order to investigate whether MCP-1 enhances collateral growth after femoral artery occlusion, 12 rabbits were randomly assigned to receive either MCP-1, PBS, or no local infusion via osmotic minipump. Seven days after occlusion, isolated hindlimbs were perfused with autologous blood at different pressures, measuring flows at maximal vasodilation via flow probe and radioactive microspheres, as well as peripheral pressures. This allowed the calculation of collateral (thigh) and peripheral (lower limb) conductances from pressure-flow tracings (slope of the curve). Collateral growth on postmortem angiograms was restricted to the thigh and was markedly enhanced with MCP-1 treatment. Both collateral and peripheral conductances were significantly elevated in animals with MCP-1 treatment compared with the control group, reaching values of nonoccluded hindlimbs after only 1 week of occlusion (collateral conductance, 70.6 +/- 19.23 versus 25.1 +/- 2.59 mL/min per 100 mm Hg; P < .01; peripheral conductance, 119.3 +/- 22.37 versus 45.4 +/- 6.80 mL/min per 100 mm Hg; P < .05). These results suggest that activation of monocytes plays an important role in collateral growth as well as in capillary sprouting. |
| | |
Authors:
|
W D Ito; M Arras; B Winkler; D Scholz; J Schaper; W Schaper |
Related Documents
:
|
21444835 - Clinical features of 8295 patients with resistant hypertension classified on the basis ... 11733395 - Collateral function in chronic total coronary occlusions is related to regional myocard... 8884555 - Responses of internal mammary artery graft flow to nitroprusside: a duplex doppler stud... 6983315 - Myocardial metabolism and hemodynamic responses to halothane or morphine anesthesia for... 2596655 - Intravenous regional analgesia with prilocaine for foot surgery. the effect of slow inj... 16222605 - Mechanisms of vascular disease in hypertension with special reference to diabetes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation research Volume: 80 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1997 Jun |
Date Detail:
|
Created Date: 1997-06-23 Completed Date: 1997-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 829-37 Citation Subset: IM |
Affiliation:
|
Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Bad Nauheim, Germany. wito@alpha.kerckhoff.mpg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiography Animals Arterial Occlusive Diseases / physiopathology* Arteries / pathology Capillaries / pathology Chemokine CCL2 / pharmacology* Collateral Circulation / drug effects* Femoral Artery* / radiography Forelimb / blood supply* Microscopy, Fluorescence Monocytes / pathology Rabbits Regional Blood Flow / drug effects Thigh / blood supply* |
| Chemical | |
Reg. No./Substance:
|
0/Chemokine CCL2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer ...
Next Document: Vascular thrombin receptor regulation in hypertensive rats.