Document Detail


Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes.
MedLine Citation:
PMID:  19228487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CC chemokine monocyte chemoattractant protein (MCP)-1/CCL2 is involved in the formation, progression, and destabilization of atheromatous plaques and plays an essential role in postinfarction remodeling. These properties generated significant interest in the potential significance of MCP-1 as a biomarker in acute coronary syndromes (ACS). Emerging evidence suggests that MCP-1 plasma levels have prognostic value in the acute and chronic phase following ACS, providing information independent of standard clinical variables. The mechanisms responsible for adverse prognosis in patients with elevated plasma MCP-1 following ACS remain unknown. High plasma MCP-1 levels may reflect a higher burden of atherosclerotic disease, may exert prothrombotic effects resulting in recurrent coronary events, or may identify patients who mount a more intense cardiac inflammatory reaction following a coronary event, resulting in enhanced adverse remodeling. Beyond its prognostic significance, the MCP-1 axis may be an attractive target for therapy in patients with ACS.
Authors:
Carlos Gonzalez-Quesada; Nikolaos G Frangogiannis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  11     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-20     Completed Date:  2009-05-15     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*
Biological Markers / blood*
Chemokine CCL2 / blood*
Humans
Grant Support
ID/Acronym/Agency:
R01 HL-76246/HL/NHLBI NIH HHS; R01 HL076246/HL/NHLBI NIH HHS; R01 HL076246-04/HL/NHLBI NIH HHS; R01 HL085440/HL/NHLBI NIH HHS; R01 HL085440-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL2 protein, human; 0/Chemokine CCL2
Comments/Corrections

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