| Monocyte chemoattractant protein-1 in the aqueous humor of patients with age-related macular degeneration. | |
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MedLine Citation:
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PMID: 22172228 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: To investigate the role of inflammation in age-related macular degeneration (AMD) by measuring the levels of cytokines in the aqueous humor. Methods: Samples of aqueous humor were collected from 34 patients with AMD and 16 age-matched control subjects undergoing cataract surgery. AMD stage (AREDS) was determined clinically, before surgery. Levels of cytokines were measured using Luminex X-MAP technology, and positive results were verified by Western blot. Results: AMD was moderate in 18 patients and advanced in 16. The advanced-AMD group was further divided into patients with active choroidal neovascularization (CNV) (n = 7), disciform scar (n = 7), or central geographic atrophy (n = 2). Higher-than-normal levels of monocyte chemoattractant protein-1 (MCP-1) in the aqueous humor were associated with advanced AMD (200 ± 140 pg/ml vs 100 ± 61 pg/ml; p = 0.03), especially active CNV (255 ± 155 pg/ml; p = 0.02), Western blot analysis verified the MCP-1 findings. Patients with disciform scar showed a trend of abnormally high levels of IL-12 (p70) (1.7 ± 2.4 pg/ml vs 0.2 ± 1 pg/ml; p = 0.07), tumor necrosis factor (TNF)-α (1.8 ± 2.4 pg/ml vs 0.3 ± 1 pg/ml; p = 0.06), and IL-8 (4.7 ± 6.4 pg/ml vs 1.2 ± 2.1 pg/ml; p = 0.08). Conclusion: Elevated levels of inflammation-related cytokines in the aqueous humor in various stages of AMD may suggest a pathogenic role of inflammation. MCP-1 may be indicative of the angiogenic phase. Further corroborative studies are required. |
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Authors:
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Michal Kramer; Murat Hasanreisoglu; Anna Feldman; Ruth Axer Siegel; Paulina Sonis; Idit Maharshak; Yehudit Monselise; Michael Gurevich; Dov Weinberger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: - ISSN: 1442-9071 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Journal compilation © 2011 Royal Australian and New Zealand College of Ophthalmologists. |
Affiliation:
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Department of Ophthalmology, Rabin Medical Center, Petach Tikva; Neurogenomic Laboratory, Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer; Laboratory of Clinical Immunology, Rabin Medical Center, Petach Tikva, and Sackler School of Medicine, Tel Aviv University, Tel Aviv; Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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